Faculty, Staff and Student Publications
Language
English
Publication Date
11-1-2024
Journal
Oral Oncology
DOI
10.1016/j.oraloncology.2024.106986
PMID
39137489
PMCID
PMC11879773
PubMedCentral® Posted Date
11-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.
Keywords
Humans, Mouth Neoplasms, Immunologic Factors, Immunotherapy, Drug Delivery Systems, Immunomodulating Agents
Published Open-Access
yes
Recommended Citation
Hussein, Nourhan I; Molina, Andrea H; Sunga, Gemalene M; et al., "Localized Intratumoral Delivery of Immunomodulators for Oral Cancer and Oral Potentially Malignant Disorders" (2024). Faculty, Staff and Student Publications. 5268.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5268
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons