Acute Kidney Injury Is Associated With Elevated Urinary Endotrophin

Authors

Amanda J Clark
Brenda Mendoza Flores
Marie Christelle Saade
Kyle Q Vu
Isaac J Pence
Ningyan Zhang
Zhiqiang An
Dawei Bu
Philipp E Scherer
Samir M Parikh

Language

English

Publication Date

11-1-2025

Journal

American Journal of Physiology-Renal Physiology

DOI

10.1152/ajprenal.00300.2025

PMID

41083270

PMCID

PMC12704364

PubMedCentral® Posted Date

12-16-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Acute kidney injury (AKI) is prevalent among hospitalized patients. Novel biomarkers are needed to diagnose AKI and target therapies. Endotrophin (ETP) is a molecule released during collagen type VI formation that may promote injury and fibrosis. Although serum ETP elevation has been associated with adverse outcomes in AKI, urinary ETP has not been assessed in AKI, nor has ETP been evaluated in a pediatric population. Urine samples were collected from a tertiary children's hospital. Medical records were reviewed, and patients who met criteria were sorted into three categories:

Keywords

Humans, Acute Kidney Injury, Male, Female, Biomarkers, Child, Child, Preschool, Peptide Fragments, Adolescent, Creatinine, Infant, Case-Control Studies, Retrospective Studies, Collagen Type VI

Published Open-Access

yes

Recommended Citation

Clark, Amanda J; Mendoza Flores, Brenda; Saade, Marie Christelle; et al., "Acute Kidney Injury Is Associated With Elevated Urinary Endotrophin" (2025). Faculty, Staff and Student Publications. 5274.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5274