Faculty, Staff and Student Publications

Language

English

Publication Date

12-1-2025

Journal

Journal of Cerebral Blood Flow & Metabolism

DOI

10.1177/0271678X251370858

PMID

40916918

PMCID

PMC12417476

PubMedCentral® Posted Date

9-8-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurological disease, and one of the primary drivers of morbidity after aneurysm rupture is the phenomenon of delayed cerebral ischemia (DCI). Significant knowledge has been gained over the past two decades of the impact of neuroinflammation in DCI; and neutrophils are now believed to play a major role. There is significant human subject data showing the rise of neutrophil related inflammatory markers and neutrophil's association with poor outcome after aSAH, but as of yet no trials involving human subjects have been done specifically targeting neutrophils. There is however a growing body of evidence in animals models that targeting neutrophils, or their byproducts such as neutrophil extracellular traps improves outcomes. This review summarizes the available evidence of neutrophil's impact in both human subjects and animal models of aSAH and should serve as an impetuous to explore clinical trials in human subjects.

Keywords

Humans, Subarachnoid Hemorrhage, Vasospasm, Intracranial, Neutrophils, Animals, Brain Ischemia, Clinical Trials as Topic, Neutrophils, subarachnoid hemorrhage, delayed cerebral ischemia, delayed neurological deficits, vasospasm, NETs

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.