Faculty, Staff and Student Publications

Language

English

Publication Date

10-1-2024

Journal

Cancer

DOI

10.1002/cncr.35389

PMID

38985794

Abstract

Background: The management of early breast cancer (BC) has witnessed an uprise in the use of neoadjuvant therapy and a remarkable reshaping of the systemic therapy postneoadjuvant treatment in the last few years, with the evolution of many controversial clinical situations that require consensus.

Methods: During the 14th Breast-Gynecological and Immuno-Oncology International Cancer Conference held in Egypt in 2022, a panel of 44 BC experts from 13 countries voted on statements concerning debatable challenges in the neo/adjuvant treatment setting. The recommendations were subsequently updated based on the most recent data emerging. A modified Delphi approach was used to develop this consensus. A consensus was achieved when ≥75% of voters selected an answer.

Results and conclusions: The consensus recommendations addressed different escalation and de-escalation strategies in the setting of neoadjuvant therapy for early BC. The recommendations recapitulate the available clinical evidence and expert opinion to individualize patient management and optimize therapy outcomes. Consensus was reached in 63% of the statements (52/83), and the rationale behind each statement was clarified.

Keywords

Humans, Breast Neoplasms, Neoadjuvant Therapy, Female, Consensus, Precision Medicine, HER2‐positive breast cancer, adjuvant therapy, breast cancer, hormone receptor‐positive breast cancer, neoadjuvant therapy, triple‐negative breast cancer

Published Open-Access

yes

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