Faculty, Staff and Student Publications

Language

English

Publication Date

8-1-2024

Journal

Arthritis Care & Research

DOI

10.1002/acr.25348

PMID

38973731

PMCID

PMC12646475

PubMedCentral® Posted Date

11-26-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Objective: We provide evidence-based recommendations regarding the treatment of interstitial lung disease (ILD) in adults with systemic autoimmune rheumatic diseases (SARDs).

Methods: We developed clinically relevant population, intervention, comparator, and outcomes questions. A systematic literature review was then performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A panel of clinicians and patients reached consensus on the direction and strength of the recommendations.

Results: Thirty-five recommendations were generated (including two strong recommendations) for first-line SARD-ILD treatment, treatment of SARD-ILD progression despite first-line ILD therapy, and treatment of rapidly progressive ILD. The strong recommendations were against using glucocorticoids in systemic sclerosis-ILD as a first-line ILD therapy and after ILD progression. Otherwise, glucocorticoids are conditionally recommended for first-line ILD treatment in all other SARDs.

Conclusion: This clinical practice guideline presents the first recommendations endorsed by the American College of Rheumatology and American College of Chest Physicians for the treatment of ILD in people with SARDs.

Keywords

Humans, Autoimmune Diseases, Evidence-Based Medicine, Glucocorticoids, Lung Diseases, Interstitial, Rheumatic Diseases, Rheumatology

Published Open-Access

yes

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