FGF5

Authors

Evelyn A Carrion
Malcolm M Moses
Richard R Behringer

Language

English

Publication Date

1-1-2024

Journal

Differentiation

DOI

10.1016/j.diff.2023.10.004

PMID

37957094

PMCID

PMC12535173

PubMedCentral® Posted Date

10-19-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

FGF5 functions as a negative regulator of the hair cycle in mammals. It is expressed in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. It functions as a signaling molecule, mediating the transition of the anagen growth phase to catagen regression phase of the hair cycle. Spontaneous and engineered FGF5 mutations in mammalian animal models result in long hair phenotypes. In humans, inherited FGF5 mutations result in trichomegaly (long eyelashes). Knockdown of fgf5 in zebrafish embryos results in inner ear alterations. Alterations in FGF5 expression are also associated with various human pathologies.

Keywords

Animals, Humans, Fibroblast Growth Factor 5, Zebrafish, Mutation, Hair Follicle, Signal Transduction, Hair, Hair cycle, Angora, Trichomegaly, Inner ear

Published Open-Access

yes

Recommended Citation

Evelyn A Carrion, Malcolm M Moses, and Richard R Behringer, "FGF5" (2024). Faculty, Staff and Student Publications. 5344.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5344