WNT7A

Authors

Naomi M Calhoun
Richard R Behringer

Language

English

Publication Date

1-1-2025

Journal

Differentiation

DOI

10.1016/j.diff.2025.100899

PMID

40815867

Abstract

WNT7A regulates numerous developmental processes. It can activate canonical and non-canonical signaling depending on context. It is expressed in the developing central nervous system, limb buds, reproductive organs, and other tissues. Spontaneous and targeted Wnt7a mutations in mouse models resulted in abnormal limbs, defects in male and female reproductive tract organs, infertility, and defects in cerebellar axon remodeling. In zebrafish, wnt7aa mutants exhibited neurogenesis and angiogenesis defects in the central nervous system. In humans, recessive WNT7A missense and nonsense mutations resulted in severe limb and pelvic bone defects. Alterations in WNT7A expression correlated with multiple types of cancer.

Keywords

Animals, Humans, Wnt Proteins, Zebrafish, Mice, Mutation, Female, Neurogenesis, Male, Gene Expression Regulation, Developmental, Limb, Nervous system, Uterus

Published Open-Access

yes

Recommended Citation

Naomi M Calhoun and Richard R Behringer, "WNT7A" (2025). Faculty, Staff and Student Publications. 5345.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5345