Faculty, Staff and Student Publications
Language
English
Publication Date
12-18-2024
Journal
Neuron
DOI
10.1016/j.neuron.2024.10.010
PMID
39504962
PMCID
PMC11659027
PubMedCentral® Posted Date
12-18-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Corticothalamic projections to sensorimotor thalamic nuclei show modest firing rates and serve to modulate the activity of thalamic relay neurons. By contrast, here we find that high-order corticothalamic projections from the prelimbic (PL) cortex to the anterior paraventricular thalamic nucleus (aPVT) maintain high-frequency activity and evoke strong synaptic excitation of aPVT neurons in rats. In a significant fraction of aPVT cells, such high-frequency excitation of PL-aPVT projections leads to a rapid decay of action potential amplitudes, followed by a depolarization block (DB) that strongly limits aPVT maximum firing rates, thereby regulating both defensive and appetitive behaviors in a frequency-dependent manner. Strong inhibitory inputs from the anteroventral portion of the thalamic reticular nucleus (avTRN) inhibit the firing rate of aPVT neurons during periods of high-spike fidelity but restore it during prominent DB, suggesting that avTRN activity can modulate the effects of PL inputs on aPVT firing rates to ultimately control motivated behaviors.
Keywords
Animals, Rats, Neurons, Neural Pathways, Action Potentials, Male, Midline Thalamic Nuclei, Rats, Sprague-Dawley, Cerebral Cortex, Thalamus
Published Open-Access
yes
Recommended Citation
Aquino-Miranda, Guillermo; Jalloul, Dounya; Zhang, Xu O; et al., "Functional Properties of Corticothalamic Circuits Targeting Paraventricular Thalamic Neurons" (2024). Faculty, Staff and Student Publications. 5353.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5353
Graphical Abstract
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