Faculty, Staff and Student Publications

Language

English

Publication Date

1-9-2026

Journal

Scientific Data

DOI

10.1038/s41597-025-06321-w

PMID

41513675

PMCID

PMC12796154

PubMedCentral® Posted Date

1-9-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Osteoradionecrosis of the jaw (ORNJ) is a radiation-induced late toxicity that can dramatically decrease patients' quality of life. Recent increases in survival rates of head and neck cancers associated with human papillomavirus (HPV) infection have resulted in a higher frequency of radiation-induced toxicities, particularly ORNJ. Recent work with Normal Tissue Complication Probability (NTCP) models and a Weibull Accelerated Failure Time (WAFT) model have further developed our understanding of ORNJ clinical/dosimetric risk factors and longitudinal features, respectively. In this data descriptor, 1129 head and neck cancer (HNC) patients received curative intent radiotherapy (RT) at MD Anderson Cancer Center and were followed up with clinical and radiological assessments at 3-6, 12, 18, 24 months, and then annually following the conclusion of RT for development of ORNJ. This data, in addition to the patients' demographic, supplementary clinical, and dosimetric information was recorded in a comma-separated value file embedded within this data descriptor. This large, longitudinal dataset is a significant resource for further systematic analysis of post-RT normal tissue outcomes in HNC.

Keywords

Humans, Osteoradionecrosis, Head and Neck Neoplasms, Male, Female, Probability, Middle Aged, Aged, Head and neck cancer, Cancer models, Outcomes research, Risk factors, Oral manifestations

Published Open-Access

yes

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