Advancing Alzheimer's Research by Improving Disease Modeling of Secondary Tauopathy

Authors

Ethan R Roy
Wei Cao

Language

English

Publication Date

1-1-2025

Journal

npj Dementia

DOI

10.1038/s44400-025-00044-w

PMID

41311528

PMCID

PMC12646961

PubMedCentral® Posted Date

11-25-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Despite decades of mechanistic investigation of Alzheimer's disease (AD), wide gaps exist in disease modeling, particularly the pathobiological arm of tau pathology. Relying on transgenic models expressing mutated forms of tau has contributed much knowledge about primary tauopathy, yet with limited relevance to human AD. To eliminate blind spots for basic and translational research, we review recent developments in this area and discuss key refinements toward next-generation AD-relevant tauopathy modeling.

Keywords

Computational biology and bioinformatics, Diseases, Neuroscience

Published Open-Access

yes

Recommended Citation

Ethan R Roy and Wei Cao, "Advancing Alzheimer's Research by Improving Disease Modeling of Secondary Tauopathy" (2025). Faculty, Staff and Student Publications. 5430.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5430