Faculty, Staff and Student Publications

Language

English

Publication Date

10-20-2025

Journal

Genome Biology

DOI

10.1186/s13059-025-03771-8

PMID

41116172

PMCID

PMC12536537

PubMedCentral® Posted Date

10-20-2025

PubMedCentral® Full Text Version

Post-print

Abstract

The field of single-cell biology is growing rapidly, generating large amounts of data from a variety of species, disease conditions, tissues, and organs. Coordinated efforts such as CZI CELLxGENE, HuBMAP, Broad Institute Single Cell Portal, and DISCO allow researchers to access large volumes of curated datasets, including more than just scRNA-seq data. These resources have created an opportunity to build and expand the computational biology ecosystem to develop tools necessary for data reuse and for extracting novel biological insights. We highlight achievements made so far, areas where further development is needed, and specific challenges that need to be overcome.

Keywords

Single-Cell Analysis, Humans, Animals, Computational Biology, Atlases as Topic, Databases, Genetic

Published Open-Access

yes

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