Faculty, Staff and Student Publications

Language

English

Publication Date

12-2-2024

Journal

Translational Vision Science & Technology

DOI

10.1167/tvst.13.12.28

PMID

39688851

PMCID

PMC11654773

PubMedCentral® Posted Date

12-17-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Inherited retinal degeneration (IRD) disease and age-related macular degeneration (AMD) are leading causes of irreversible vision loss and blindness. Although significant progress has advanced the field in the past 5 years, significant challenges remain. The current article reviews the accomplishments and research advances that have fueled the development of treatments for patients with IRD and AMD, including the first approved gene-augmentation treatment for RPE65-related retinal degeneration and complement inhibition therapies to slow progression of geographic atrophy (GA) in AMD. The article outlines opportunities to address gaps and unmet needs that should lead to additional progress toward the development of treatments for patients with IRDs and non-neovascular AMD in the future.

Keywords

Humans, Macular Degeneration, Retinal Degeneration, Genetic Therapy, Geographic Atrophy, cis-trans-Isomerases, Retinoid Isomerohydrolase, inherited retinal degeneration (IRD) diseases, age-related macular degeneration (AMD), gap analysis

Published Open-Access

yes

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