Molecularly Targeted Therapy in Acute Myeloid Leukemia: Current Treatment Landscape and Mechanisms of Response and Resistance

Authors

Curtis A Lachowiez
Courtney D DiNardo
Sanam Loghavi

Language

English

Publication Date

3-6-2023

Journal

Cancers

DOI

10.3390/cancers15051617

PMID

36900407

PMCID

PMC10001191

PubMedCentral® Posted Date

3-6-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Treatment for acute myeloid leukemia (AML) has evolved rapidly over the last decade as improved understanding of cytogenetic and molecular drivers of leukemogenesis refined survival prognostication and enabled development of targeted therapeutics. Molecularly targeted therapies are now approved for the treatment of FLT3 and IDH1/2-mutated AML and additional molecularly and cellularly targeted therapeutics are in development for defined patient subgroups. Alongside these welcome therapeutic advancements, increased understanding of leukemic biology and treatment resistance has resulted in clinical trials investigating combinations of cytotoxic, cellular, and molecularly targeted therapeutics resulting in improved response and survival outcomes in patients with AML. Herein, we comprehensively review the current landscape of IDH and FLT3 inhibitors in clinical practice for the treatment of AML, highlight known resistance mechanisms, and discuss new cellular or molecularly targeted therapies currently under investigation in ongoing early phase clinical trials.

Keywords

acute myeloid leukemia, IDH inhibitor, FLT3 inhibitor, targeted therapy

Published Open-Access

yes

Recommended Citation

Curtis A Lachowiez, Courtney D DiNardo, and Sanam Loghavi, "Molecularly Targeted Therapy in Acute Myeloid Leukemia: Current Treatment Landscape and Mechanisms of Response and Resistance" (2023). Faculty, Staff and Student Publications. 5562.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5562