Faculty, Staff and Student Publications

Language

English

Publication Date

11-1-2025

Journal

Cancer

DOI

10.1002/cncr.70113

PMID

41129068

PMCID

PMC12548704

PubMedCentral® Posted Date

10-23-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Advances in the prognostication, monitoring, and treatment of both the acute and chronic leukemias have led to drastically improved outcomes over the past 2 decades. With the advent of targeted therapies, including antibodies such as blinatumomab and inotuzumab and small molecule inhibitors, such as the BCR::ABL1 tyrosine kinase inhibitors, Bruton tyrosine kinase inhibitors, and venetoclax, the treatment landscape of leukemia has drastically changed, improving survival outcomes while relying less on overall chemotherapy intensity in many leukemia types. This progress has allowed the categorization of more leukemia types as favorable (i.e., chronic lymphocytic leukemia, younger acute lymphoblastic leukemia [patients younger than 60 years], and Philadelphia chromosome-positive acute lymphoblastic leukemia) in addition to the traditional favorable subtypes of acute promyelocytic leukemia, core-binding factor acute myelocytic leukemia, chronic myelocytic leukemia, and hairy cell leukemia. Advancements in the treatment of TP53-mutated, MECOM-rearranged, and treated secondary AML are still needed to improve outcomes in these adverse risk groups. The authors also review the recent progress in the treatment of the acute and chronic leukemias.

Keywords

Humans, Leukemia, Protein Kinase Inhibitors, Molecular Targeted Therapy, Prognosis, acute lymphoblastic leukemia, acute myeloid leukemia, chimeric antigen receptor (CAR) T‐cell therapy, chronic lymphocytic leukemia, chronic myeloid leukemia, monoclonal antibody, targeted therapy

Published Open-Access

yes

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