Faculty, Staff and Student Publications

Language

English

Publication Date

11-25-2025

Journal

Blood Cancer Journal

DOI

10.1038/s41408-025-01429-z

PMID

41290614

PMCID

PMC12780004

PubMedCentral® Posted Date

11-25-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Venetoclax-based doublets with azacitidine or low dose cytarabine are the standard of care for the treatment of acute myeloid leukemia (AML) in older patients or those unfit for intensive chemotherapy. However, some patients do not attain complete remission, and over time, most patients relapse. Frontline triplet therapy incorporating a targeted therapy (FLT3, IDH or menin inhibitor) is an emerging treatment concept under investigation for this population. Initial triplet regimens have yielded encouraging composite complete remission and measurable residual disease negativity rates, enabling the transition to allogeneic stem cell transplantation for eligible patients. While effective, triplets are associated with myelosuppression and cytopenia-related toxicities, which can affect treatment tolerability and quality of life. In this review, we summarize the available evidence for triplet therapy in AML and offer our recommendations on the practical application of triplets in clinical practice, with particular focus on adjustments to dosing schedules in induction and continuation cycles. We also outline drug-specific adverse effects and interactions based on emerging clinical data to help guide the clinician, given the increasing use of novel combination therapies.

Keywords

Humans, Leukemia, Myeloid, Acute, Antineoplastic Combined Chemotherapy Protocols, Cytarabine, Combination drug therapy, Molecularly targeted therapy

Published Open-Access

yes

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