Therapeutic Approaches to Modulate the Immune Microenvironment in Gliomas

Authors

Andreas Sarantopoulos
Chibawanye Ene
Elisa Aquilanti

Publication Date

10-23-2024

Journal

npj Precision Oncology

DOI

10.1038/s41698-024-00717-4

PMID

39443641

PMCID

PMC11500177

PubMedCentral® Posted Date

10-23-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Immunomodulatory therapies, including immune checkpoint inhibitors, have drastically changed outcomes for certain cancer types over the last decade. Gliomas are among the cancers that have seem limited benefit from these agents, with most trials yielding negative results. The unique composition of the glioma immune microenvironment is among the culprits for this lack of efficacy. In recent years, several efforts have been made to improve understanding of the glioma immune microenvironment, aiming to pave the way for novel therapeutic interventions. In this review, we discuss some of the main components of the glioma immune microenvironment, including macrophages, myeloid-derived suppressor cells, neutrophils and microglial cells, as well as lymphocytes. We then provide a comprehensive overview of novel immunomodulatory agents that are currently in clinical development, namely oncolytic viruses, vaccines, cell-based therapies such as CAR-T cells and CAR-NK cells as well as antibodies and peptides.

Keywords

Cancer microenvironment, CNS cancer, Tumour immunology

Published Open-Access

yes

Recommended Citation

Andreas Sarantopoulos, Chibawanye Ene, and Elisa Aquilanti, "Therapeutic Approaches to Modulate the Immune Microenvironment in Gliomas" (2024). Faculty, Staff and Student Publications. 5624.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5624