Faculty, Staff and Student Publications
Language
English
Publication Date
10-1-2024
Journal
Neuropathology
DOI
10.1111/neup.12968
PMID
38414131
Abstract
Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35-year-old woman who presented with new-onset hearing loss and ringing in her right ear. Magnetic resonance imaging identified a non-enhancing mass involving the gray matter and subcortical white matter of the left middle frontal gyrus. Additionally, tiny clustered nodules were noted along the underlying subcortical ribbon and superficial subcortical white matter of the left superior frontal gyrus. The patient underwent a left frontal craniotomy and complete resection of the mass. Histologic examination of the resected specimen demonstrated a collision tumor consisting of a diffuse astrocytoma (isocitrate dehydrogenase [IDH] mutant, central nervous system [CNS] World Health Organization [WHO] grade 2) and an MVNT, with the latter demonstrating characteristic morphologic and immunohistochemical features.
Keywords
Humans, Astrocytoma, Female, Adult, Brain Neoplasms, Isocitrate Dehydrogenase, Mutation, Neoplasms, Multiple Primary, astrocytoma, magnetic resonance imaging, multinodular, neuronal tumor, vacuoles
Published Open-Access
yes
Recommended Citation
Kumar, Vinodh A; Perez, Alejandro; Young, Angela L; et al., "Collision Tumor: Multinodular and Vacuolating Neuronal Tumor With Isocitrate Dehydrogenase-Mutant Diffuse Astrocytoma" (2024). Faculty, Staff and Student Publications. 5653.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5653
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