Faculty, Staff and Student Publications
Language
English
Publication Date
11-4-2024
DOI
10.1136/ijgc-2024-005599
PMID
39084695
PMCID
PMC11534538
PubMedCentral® Posted Date
5-4-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Objective: To describe sociodemographic and racial disparities in receipt of poly ADP-ribose polymerase inhibitors (PARPi) and bevacizumab among insured patients with ovarian cancer.
Methods: This retrospective study used the Surveillance, Epidemiology, and End Results (SEER)-Medicare database to identify patients with advanced stage, high grade serous ovarian cancer diagnosed between 2010 and 2019. The primary outcome of interest was receipt of PARPi or bevacizumab at any time after diagnosis. χ2 tests were used to compare categorical variables. Factors independently associated with the receipt of PARPi and/or bevacizumab were identified using a multivariable logistic regression.
Results: The cohort included 6242 patients; 276 (4.4%) received PARPi, 2142 (34.3%) received bevacizumab, and 389 (6.2%) received both. Receipt of either targeted treatment increased over the study period. On univariate analysis, patients who received either targeted therapy were younger (63% vs 48% aged < 75 years; p< 0.001), had a lower comorbidity index (86% vs 80% Charlson Comorbidity Index 0-1; p< 0.001), and higher socioeconomic status (74% vs 71% high socioeconomic status; p=0.047) compared with those who did not receive targeted therapy. In the multivariable model, non-Hispanic black patients were less likely than non-Hispanic white patients to receive either targeted therapy (odds ratio 0.77; 95% confidence interval 0.61 to 0.98; p=0.032). Older patients (aged >74 years) were also less likely to receive PARPi or bevacizumab compared with those aged 65-69 years (all p< 0.001).
Conclusion: Sociodemographic and racial disparities exist in receipt of PARPi and bevacizumab among patients with advanced ovarian cancer insured by Medicare. As targeted therapies become more commonly used, a widening disparity gap is likely.
Keywords
Humans, Female, Aged, Ovarian Neoplasms, United States, Medicare, Retrospective Studies, Healthcare Disparities, Bevacizumab, Aged, 80 and over, SEER Program, Poly(ADP-ribose) Polymerase Inhibitors, Molecular Targeted Therapy, Socioeconomic Factors, Carcinoma, Ovarian Epithelial, Ovarian Cancer, Retrospective Study
Published Open-Access
yes
Recommended Citation
Knisely, Anne; Wu, Chi-Fang; Kanbergs, Alexa; et al., "Racial and Sociodemographic Disparities in the Use of Targeted Therapies in Advanced Ovarian Cancer Patients With Medicare" (2024). Faculty, Staff and Student Publications. 5755.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5755
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