Ras-Membrane Interaction and Oligomerization: There Is More Than Meets the Eye

Authors

Abraham C Sianoya
Vijay K Bhardwaj
Alemayehu A Gorfe

Publication Date

8-29-2025

Journal

Biochemical Society Transactions

DOI

10.1042/BST20253030

PMID

40801144

PMCID

PMC12493186

PubMedCentral® Posted Date

8-13-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Membrane association is fundamental to Rat sarcoma (RAS) function, driving both its physiologic signaling and oncogenic transformation. This review consolidates recent advances in the study of RAS-membrane interactions, emphasizing the molecular mechanisms underlying its membrane engagement and oligomerization. We first discuss the roles of RAS lipid modification and conformational diversity of its intrinsically disordered C-terminus in these processes, and we then examine the debate surrounding RAS dimerization and its potential role in the formation of higher-order oligomers. By integrating emerging insights into these issues, we offer our own perspectives on the driving forces of RAS oligomerization and propose potential new avenues for developing targeted therapies for RAS-driven cancers.

Keywords

Humans, ras Proteins, Animals, Protein Multimerization, Cell Membrane, Signal Transduction, conformational dynamics, membrane lipids, plasma membrane, RAS protein, signal transduction

Published Open-Access

yes

Recommended Citation

Abraham C Sianoya, Vijay K Bhardwaj, and Alemayehu A Gorfe, "Ras-Membrane Interaction and Oligomerization: There Is More Than Meets the Eye" (2025). Faculty, Staff and Student Publications. 5760.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5760