Epigenetic Regulation of Heart Failure

Authors

Manisha Deogharia
Priyatansh Gurha

Publication Date

7-1-2024

Journal

Current Opinion in Cardiology

DOI

10.1097/HCO.0000000000001150

PMID

38606626

PMCID

PMC11150090

PubMedCentral® Posted Date

7-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Purpose of review: The studies on chromatin-modifying enzymes and how they respond to different stimuli within the cell have revolutionized our understanding of epigenetics. In this review, we provide an overview of the recent studies on epigenetic mechanisms implicated in heart failure.

Recent findings: We focus on the major mechanisms and the conceptual advances in epigenetics as evidenced by studies in humans and mouse models of heart failure. The significance of epigenetic modifications and the enzymes that catalyze them is also discussed. New findings from the studies of histone lysine demethylases demonstrate their significance in regulating fetal gene expression, as well as their aberrant expression in adult hearts during HF. Similarly, the relevance of histone deacetylases inhibition in heart failure and the role of HDAC6 in cardio-protection are discussed. Finally, the role of LMNA (lamin A/C), a nuclear membrane protein that interacts with chromatin to form hundreds of large chromatin domains known as lamin-associated domains (LADs), and 3D genome structure in epigenetic regulation of gene expression and heart failure is discussed.

Summary: Epigenetic modifications provide a mechanism for responding to stress and environmental variation, enabling reactions to both external and internal stimuli, and their dysregulation can be pathological as in heart failure. To gain a thorough understanding of the pathological mechanisms and to aid in the development of targeted treatments for heart failure, future research on studying the combined effects of numerous epigenetic changes and the structure of chromatin is warranted.

Keywords

Heart Failure, Humans, Epigenesis, Genetic, Animals, Histone modifications, KDM5, Cardiomyopathies, Genome organization

Published Open-Access

yes

Recommended Citation

Manisha Deogharia and Priyatansh Gurha, "Epigenetic Regulation of Heart Failure" (2024). Faculty, Staff and Student Publications. 5785.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5785