Evaluating Bone Marrow Dosimetry With the Addition of Bone Marrow Structures to the Medical Internal Radiation Dose Phantom

Authors

Kristine L Ferrone
Charles E Willis
Fada Guan
Jingfei Ma
Leif E Peterson
Stephen F Kry

Language

English

Publication Date

3-1-2023

Journal

Precision Radiation Oncology

DOI

10.1002/pro6.1189

PMID

40336618

PMCID

PMC11935159

PubMedCentral® Posted Date

3-17-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Background: Reliable estimates of radiation dose to bone marrow are critical to understanding the risk of radiation-induced cancers. Although the medical internal radiation dose phantom is routinely used for dose estimation, bone marrow is not defined in the phantom. Consequently, methods of indirectly estimating bone marrow dose have been implemented based on dose to surrogate volumes or average dose to soft tissue.

Methods: In this study, new bone marrow structures were implemented and evaluated to the medical internal radiation dose phantom in geant4, offering improved fidelity. The dose equivalent to the bone marrow was calculated across medical, occupational, and space radiation exposure scenarios, and compared with results using prior indirect estimation methods.

Conclusion: Our results show that bone marrow dose may be overestimated by up to a factor of three when using the traditional methods when compared with the improved fidelity medical internal radiation dose method, specifically at clinical x-ray energies.

Keywords

computational phantoms, Monte Carlo simulations, radiation dosimetry

Published Open-Access

yes

Recommended Citation

Ferrone, Kristine L; Willis, Charles E; Guan, Fada; et al., "Evaluating Bone Marrow Dosimetry With the Addition of Bone Marrow Structures to the Medical Internal Radiation Dose Phantom" (2023). Faculty, Staff and Student Publications. 5794.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/5794