Faculty, Staff and Student Publications

Language

English

Publication Date

2-18-2025

Journal

ACS Nano

DOI

10.1021/acsnano.4c11630

PMID

39869032

PMCID

PMC12002402

PubMedCentral® Posted Date

2-18-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Extracellular vesicles (EVs) are cell derived nanovesicles which are implicated in both physiological and pathological intercellular communication, including the initiation, progression, and metastasis of cancer. The exchange of biomolecules between stromal cells and cancer cells via EVs can provide a window to monitor cancer development in real time for better diagnostic and interventional strategies. In addition, the process of secretion and internalization of EVs by stromal and cancer cells in the tumor microenvironment (TME) can be exploited for delivering therapeutics. EVs have the potential to provide a targeted, biocompatible, and efficient delivery platform for the treatment of cancer and other diseases. Natural as well as engineered EVs as nanomedicine have immense potential for disease intervention. Here, we provide an overview of current knowledge of EVs' function in cancer progression, diagnostic and therapeutic applications for EVs in the cancer setting, as well as current EV engineering strategies.

Keywords

Humans, Extracellular Vesicles, Neoplasms, Bioengineering, Tumor Microenvironment, Animals, Nanomedicine, Extracellular vesicles (EVs), cancer, diagnosis, monitoring, tumor microenvironment (TME), immune microenvironment, cancer immunotherapy, drug delivery, cargo loading methods, large scale production

Published Open-Access

yes

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