The Primary Cilia: Orchestrating Cranial Neural Crest Cell Development

Authors

Hiroyuki Yamaguchi
Matthew D Meyer
William B Barrell
Maryam Faisal
Rebecca Berdeaux
Karen J Liu
Yoshihiro Komatsu

Language

English

Publication Date

1-1-2025

Journal

Differentiation

DOI

10.1016/j.diff.2024.100818

PMID

39500655

PMCID

PMC11911094

PubMedCentral® Posted Date

3-1-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

Keywords

Neural Crest, Cilia, Animals, Humans, Cell Differentiation, Ciliopathies, Skull, Cilia, Ciliogenesis, Cranial neural crest cells, Craniofacial development, Signal transduction

Published Open-Access

yes

Recommended Citation

Yamaguchi, Hiroyuki; Meyer, Matthew D; Barrell, William B; et al., "The Primary Cilia: Orchestrating Cranial Neural Crest Cell Development" (2025). Faculty, Staff and Student Publications. 6005.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6005