Faculty, Staff and Student Publications

Language

English

Publication Date

4-16-2024

Journal

Aging and Disease

DOI

10.14336/AD.2024.0065

PMID

38739931

PMCID

PMC11964433

PubMedCentral® Posted Date

4-16-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Diabetic foot ulcers (DFUs) are a prevalent and profoundly debilitating complication that afflicts individuals with diabetes mellitus (DM). These ulcers are associated with substantial morbidity, recurrence rates, disability, and mortality, imposing substantial economic, psychological, and medical burdens. Timely detection and intervention can mitigate the morbidity and disparities linked to DFU. Nevertheless, current therapeutic approaches for DFU continue to grapple with multifaceted limitations. A growing body of evidence emphasizes the crucial role of cellular senescence in the pathogenesis of chronic wounds. Interventions that try to delay cellular senescence, eliminate senescent cells (SnCs), or suppress the senescence-associated secretory phenotype (SASP) have shown promise for helping chronic wounds to heal. In this context, targeting cellular senescence emerges as a novel therapeutic strategy for DFU. In this comprehensive review, we look at the pathology and treatment of DFU in a systematic way. We also explain the growing importance of investigating SnCs in DFU and highlight the great potential of senotherapeutics that target SnCs in DFU treatment. The development of efficacious and safe senotherapeutics represents a pioneering therapeutic approach aimed at enhancing the quality of life for individuals affected by DFU.

Keywords

Humans, Diabetic Foot, Senotherapeutics, Wound Healing, Cellular Senescence, Quality of Life, Senescence-Associated Secretory Phenotype, cellular senescence, diabetic foot ulcer, senescent cells, senolytic, senomorphic, wound healing

Published Open-Access

yes

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