Functional, Pharmacogenomic, and Immune Landscapes of Long Non-Coding RNAs in Cancer

Authors

Runhao Wang
Mei Luo
Yuan Liu
Jingwen Yang
Yamei Chen
Chengxuan Chen
Lifei Ma
Stephanie Ding
James Wengler
Yong Zang
Bora Lim
Wenbo Li
Liuqing Yang
Chunru Lin
Lixia Diao
Leng Han

Language

English

Publication Date

1-1-2026

Journal

Advanced Science

DOI

10.1002/advs.202513414

PMID

41270088

PMCID

PMC12866694

PubMedCentral® Posted Date

11-21-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer, with significant potential as diagnostic, prognostic, and therapeutic targets. Here, this work systematically analyzes lncRNA associations with targeted therapies and immunotherapies across 33 cancer types using The Cancer Genome Atlas (TCGA) and real-world datasets. This work identifies 53,173 lncRNA-pathway associations, millions of lncRNA-drug response associations (via CancerRxTissue and VAEN), and extensive correlations with immune checkpoints and infiltration. This work further identifies 69 lncRNAs associated with immunotherapy response and 2,611 differentially expressed lncRNAs between low and high objective response rate (ORR) groups. Additionally, two lncRNAs are correlated with immune-related adverse events (irAEs), and 1,376 lncRNAs exhibited expression differences between cancers with low and high irAE risk. To facilitate further research, this work develops PILNC (https://hanlaboratory.com/PILNC), a comprehensive web portal enabling exploration of lncRNA associations with cancer pathways, drug responses, immune features, and immunotherapy outcomes.

Keywords

Humans, RNA, Long Noncoding, Neoplasms, Immunotherapy, Gene Expression Regulation, Neoplastic, Pharmacogenetics, cancer signaling pathways, drug response, immune checkpoints, immune infiltration, immunotherapy efficacy, irAE, LncRNAs

Published Open-Access

yes

Recommended Citation

Wang, Runhao; Luo, Mei; Liu, Yuan; et al., "Functional, Pharmacogenomic, and Immune Landscapes of Long Non-Coding RNAs in Cancer" (2026). Faculty, Staff and Student Publications. 6143.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6143