Faculty, Staff and Student Publications
Language
English
Publication Date
11-28-2024
Journal
Cancer Letters
DOI
10.1016/j.canlet.2024.217304
PMID
39426663
PMCID
PMC11898246
PubMedCentral® Posted Date
11-28-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs primarily known for their role in the chemical modification of other RNAs. Recent studies suggested that snoRNAs may play a broader role in anti-cancer treatments such as targeted therapies and immunotherapies. Despite these insights, the comprehensive landscape of snoRNA associations with drug response and immunotherapy outcomes remains unexplored. In this study, we identified 79,448 and 75,185 associations between snoRNAs and drug response using data from VAEN and CancerRxTissue, respectively. Additionally, we discovered 29,199 associations between snoRNAs and immune checkpoint genes and 47,194 associations between snoRNAs and immune cell infiltrations. Sixteen snoRNAs were significantly correlated with immunotherapy objective response rate (ORR), and 92 snoRNAs showed significantly differential expression between cancers with high and low ORR. Furthermore, we identified 17 snoRNAs with significantly differential expression between cancer types with high and low immune-related adverse event (irAE) reporting odds ratio (ROR). Several snoRNAs, such as SNORD92, and SNORD83B, may represent promising biomarkers or therapeutic targets that needs further investigation. To facilitate further research, we developed a user-friendly portal, Pharmacogenomic and Immune Landscape of SnoRNA (PISNO, https://hanlaboratory.com/PISNO/), enabling researchers to visualize, browse, and download multi-dimensional data. This study highlights the potential of snoRNAs as biomarkers or therapeutic targets, paving the way for more effective and personalized anti-cancer treatments.
Keywords
Humans, RNA, Small Nucleolar, Neoplasms, Immunotherapy, Pharmacogenetics, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Antineoplastic Agents, SnoRNA, Drug response, Immune checkpoint, Immune infiltration, Immunotherapy efficacy, irAE
Published Open-Access
yes
Recommended Citation
Wang, Runhao; Chen, Chengxuan; Liu, Yuan; et al., "The Pharmacogenomic and Immune Landscape of snoRNAs in Human Cancers" (2024). Faculty, Staff and Student Publications. 6157.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6157
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