Faculty, Staff and Student Publications

Language

English

Publication Date

4-1-2026

Journal

Annals of Surgical Oncology

DOI

10.1245/s10434-025-18916-z

PMID

41455847

PMCID

PMC12866965

PubMedCentral® Posted Date

2-4-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

BACKGROUND: In patients with hormone receptor-positive (HR

PATIENTS AND METHODS: We performed a retrospective review of patients with clinical stage I-III, HR

RESULTS: A total of 230 patients were included; 120 (52.2%) were clinically node-negative (cN0), while 110 (47.8%) were clinically node-positive (cN+). In the cN+ group, 7.3% (8/110) had a nodal pathologic complete response (pCR). In total, 76.4% (84/110) in the cN+ group underwent axillary lymph node dissection (ALND) as the initial axillary procedure, and 90.9% (100/110) underwent ALND overall. In total, 98.3% (118/120) with cN0 disease underwent sentinel lymph node dissection (SLND), and 28 (23.7%) had positive nodes. A total of 64.3% (18/28) of cN0 patients with a positive SLN underwent ALND. There were four local-regional recurrences (LRR) in the entire cohort, yielding a 5-year LRR rate of 2.2%, and it did not differ between cN0 and cN+ (2.0% versus 2.2%, p >0.05). The distant recurrence rate was higher in cN+ compared with the cN0 group (15.0% versus 6.9%, p = 0.03). The 5-year overall survival (OS) was 79.5% for the entire cohort and was higher for cN0 compared with cN+ patients (88.4% versus 69.7%, p = 0.004).

CONCLUSIONS: The 5-year LRR rate was extremely low for the entire cohort, suggesting that NET is an oncologically safe strategy for patients with HR

Keywords

Humans, Female, Breast Neoplasms, Neoadjuvant Therapy, Retrospective Studies, Middle Aged, Axilla, Lymph Node Excision, Antineoplastic Agents, Hormonal, Adult, Aged, Follow-Up Studies, Prognosis, Erb-b2 Receptor Tyrosine Kinases, Receptors, Estrogen, Lymphatic Metastasis, Receptors, Progesterone, Sentinel Lymph Node Biopsy, Survival Rate, Neoadjuvant Endocrine Therapy (NET), Axilla, Breast Cancer

Published Open-Access

yes

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