Ovarian Cancer Metastasis: Looking Beyond the Surface

Authors

Emine Bayraktar
Sisy Chen
Sara Corvigno
Jinsong Liu
Anil K Sood

Publication Date

10-14-2024

Journal

Cancer Cell

DOI

10.1016/j.ccell.2024.08.016

PMID

39270645

Abstract

Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC). Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including peritoneal, hematogenous, lymphatic, and nerve-related. Understanding the underlying mechanisms is necessary to improve treatment strategies for this challenging disease.

Keywords

Humans, Female, Ovarian Neoplasms, Neoplasm Metastasis, Animals, Cystadenocarcinoma, Serous

Published Open-Access

yes

Recommended Citation

Bayraktar, Emine; Chen, Sisy; Corvigno, Sara; et al., "Ovarian Cancer Metastasis: Looking Beyond the Surface" (2024). Faculty, Staff and Student Publications. 6188.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6188