Mutant p53 Gain of Function: Why Many See It, Why Some Do Not

Authors

Guillermina Lozano
Carol Prives
Kanaga Sabapathy

Language

English

Publication Date

6-3-2025

Journal

Cancer Discovery

DOI

10.1158/2159-8290.CD-24-1638

PMID

40287981

PMCID

PMC12133405

PubMedCentral® Posted Date

12-3-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Mutations in the TP53 tumor-suppressor gene in human cancer are unique in that 60% to 70% are of the missense variety, resulting in a full-length protein that is often highly expressed in patients' tumors. These missense mutant proteins often exhibit pro-oncogenic activities (referred to as gain of function) in mouse models and human cell lines and correlate with poor cancer prognosis in some cases.

Keywords

Humans, Tumor Suppressor Protein p53, Animals, Neoplasms, Gain of Function Mutation, Mice, Mutation

Published Open-Access

yes

Recommended Citation

Guillermina Lozano, Carol Prives, and Kanaga Sabapathy, "Mutant p53 Gain of Function: Why Many See It, Why Some Do Not" (2025). Faculty, Staff and Student Publications. 6221.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6221