Shape Anisotropy-Governed High-Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs

Authors

Saumya Nigam
Jeotikanta Mohapatra
Ashley V Makela
Hanaan Hayat
Jessi Mercedes Rodriguez
Aixia Sun
Elizabeth Kenyon
Nathan A Redman
Dana Spence
George Jabin
Bin Gu
Mohamed Ashry
Lorenzo F Sempere
Arijit Mitra
Jinxing Li
Jiahui Chen
Guo-Wei Wei
Steven Bolin
Brett Etchebarne
J Ping Liu
Christopher H Contag
Ping Wang

Language

English

Publication Date

2-1-2024

Journal

Small

DOI

10.1002/smll.202305300

PMID

37735143

PMCID

PMC10842459

PubMedCentral® Posted Date

2-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19) has shown extensive lung manifestations in vulnerable individuals, putting lung imaging and monitoring at the forefront of early detection and treatment. Magnetic particle imaging (MPI) is an imaging modality, which can bring excellent contrast, sensitivity, and signal-to-noise ratios to lung imaging for the development of new theranostic approaches for respiratory diseases. Advances in MPI tracers would offer additional improvements and increase the potential for clinical translation of MPI. Here, a high-performance nanotracer based on shape anisotropy of magnetic nanoparticles is developed and its use in MPI imaging of the lung is demonstrated. Shape anisotropy proves to be a critical parameter for increasing signal intensity and resolution and exceeding those properties of conventional spherical nanoparticles. The 0D nanoparticles exhibit a 2-fold increase, while the 1D nanorods have a > 5-fold increase in signal intensity when compared to VivoTrax. Newly designed 1D nanorods displayed high signal intensities and excellent resolution in lung images. A spatiotemporal lung imaging study in mice revealed that this tracer offers new opportunities for monitoring disease and guiding intervention.

Keywords

Mice, Animals, Anisotropy, Diagnostic Imaging, Magnetics, Nanoparticles, Magnetic Phenomena, Magnetite Nanoparticles, Magnetic Resonance Imaging, Aerosols, Lung imaging, Magnetic particle imaging, Nanorods, Superparamagnetic iron oxide nanoparticles

Published Open-Access

yes

Recommended Citation

Nigam, Saumya; Mohapatra, Jeotikanta; Makela, Ashley V; et al., "Shape Anisotropy-Governed High-Performance Nanomagnetosol for In Vivo Magnetic Particle Imaging of Lungs" (2024). Faculty, Staff and Student Publications. 6237.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6237