Faculty, Staff and Student Publications
Language
English
Publication Date
12-1-2025
Journal
Molecular Psychiatry
DOI
10.1038/s41380-025-03200-z
PMID
40897863
PMCID
PMC12602333
PubMedCentral® Posted Date
9-2-2025
PubMedCentral® Full Text Version
Post-print
Abstract
During cortical development, newly born neurons migrate radially or tangentially from their origin to expand the cortex. Simultaneously, neuron-derived factors support angiogenesis, and an elaborate network of blood cerebral vessels develops in the cortex. Traditionally, blood cerebral vessels were considered to support the growing cortex or migrating neurons by providing nutrients and oxygen. However, recent studies have shed light on Endothelial cells' influence on cortical development; they guide neuronal migration by providing molecular cues and structural support. Here, we review the current understanding of how CNS cerebral vessels support neurogenesis, neuronal migration, and the formation of the six-layer cortical structure during development. Additionally, we explore current knowledge regarding the vascular role in neurodevelopmental disorders, including autism spectrum disorder, attention deficit hyperactivity disorder, and schizophrenia.
Keywords
Humans, Schizophrenia, Cell Movement, Neurodevelopmental Disorders, Neurons, Neurogenesis, Attention Deficit Disorder with Hyperactivity, Cerebral Cortex, Animals, Autistic Disorder, Endothelial Cells, Neuroscience, Autism spectrum disorders
Published Open-Access
yes
Recommended Citation
Ahirwar, Lalit K; Blackburn, Spiros L; McBride, Devin W; et al., "Reviewing Vascular Influences on Neuronal Migration, Cortical Development, and Neurodevelopmental Disorders: Focus on Autism, ADHD and Schizophrenia" (2025). Faculty, Staff and Student Publications. 6250.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6250
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