CAMs in Command: Aging Brain Macrophages Fine-Tune Stroke Immune Responses

Authors

Rodney M Ritzel
Danye Jiang
Louise D McCullough

Language

English

Publication Date

12-1-2024

Journal

Trends in Neurosciences

DOI

10.1016/j.tins.2024.10.002

PMID

39443199

PMCID

PMC11631633

PubMedCentral® Posted Date

12-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Central nervous system-associated macrophages (CAMs) are a unique subset of immune cells located at the interface between the blood and the brain parenchyma. In a recent study in mice, Levard and colleagues found that CAMs regulate immune cell trafficking, endothelial activation, and antigen presentation following stroke exclusively in aged animals, underscoring the importance of using translationally relevant models for studying age-related diseases.

Keywords

Animals, Aging, Macrophages, Stroke, Humans, Brain, Mice, ischemic stroke, boarder-associated macrophages, neuroimmune responses, antigen presentation, leukocyte trafficking, cell adhesion

Published Open-Access

yes

Recommended Citation

Rodney M Ritzel, Danye Jiang, and Louise D McCullough, "CAMs in Command: Aging Brain Macrophages Fine-Tune Stroke Immune Responses" (2024). Faculty, Staff and Student Publications. 6255.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6255