The Dynamics of Tubulogenesis in Development and Disease

Authors

Adrian Romero
Brandy L Walker
Vanja Krneta-Stankic
Kamryn Gerner-Mauro
Lydia Youmans
Rachel K Miller

Language

English

Publication Date

2-1-2025

Journal

Development

DOI

10.1242/dev.202820

PMID

39959988

PMCID

PMC11883272

PubMedCentral® Posted Date

2-17-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Tubes are crucial for the function of many organs in animals given their fundamental roles in transporting and exchanging substances to maintain homeostasis within an organism. Therefore, the development and maintenance of these tube-like structures within organs is a vital process. Tubes can form in diverse ways, and advances in our understanding of the molecular and cellular mechanisms underpinning these different modes of tubulogenesis have significant impacts in many biological contexts, including development and disease. This Review discusses recent progress in understanding developmental mechanisms underlying tube formation.

Keywords

Animals, Humans, Organogenesis, Signal Transduction, Tubulogenesis, Morphogenesis, Cell polarity, Mechanical forces, Lumen

Published Open-Access

yes

Recommended Citation

Romero, Adrian; Walker, Brandy L; Krneta-Stankic, Vanja; et al., "The Dynamics of Tubulogenesis in Development and Disease" (2025). Faculty, Staff and Student Publications. 6286.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6286