Faculty, Staff and Student Publications
Language
English
Publication Date
9-12-2025
Journal
Aging
DOI
10.18632/aging.206319
PMID
40952372
PMCID
PMC12705187
PubMedCentral® Posted Date
9-12-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of misfolded proteins in the brain. Recently, the impact of blood components in the progression of this disease has come to attention. This study investigates the effects of infusing blood from young and old wild-type mice into transgenic mice that model AD brain amyloidosis. Impaired memory and Aβ accumulation were observed in mice infused with blood from old donors. A proteomic analysis in the brain of these mice identified alterations in components related to synaptogenesis and the endocannabinoid system. The α2δ2 protein, associated with neuronal calcium regulation, was validated as a possible mediator of the observed effects. This study highlights the influence of blood in AD pathology and the identification of potential therapeutic targets.
Keywords
Animals, Alzheimer Disease, Mice, Transgenic, Mice, Amyloid beta-Peptides, Brain, Disease Models, Animal, Aging, Amyloidosis, Proteomics, Alzheimer’s disease, amyloid-β, neurodegeneration, protein misfolding, blood infusion, therapeutic targets
Published Open-Access
yes
Recommended Citation
Pizarro, Matias; Gomez-Gutierrez, Ruben; Caviedes, Ariel; et al., "Infusion of Blood From Young and Old Mice Modulates Amyloid Pathology" (2025). Faculty, Staff and Student Publications. 6304.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6304
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