Bone Marrow Endosteum Houses Hedgehog-Susceptible Dlx5-Expressing Osteoblast Precursor Cells

Authors

Keita Kondo
Yuki Matsushita
Shion Orikasa
Yuta Nakai
Aiko Kuroda
Shinsuke Ohba
Wanida Ono
Noriaki Ono

Language

English

Publication Date

2-27-2026

Journal

Communications Biology

DOI

10.1038/s42003-026-09649-0

PMID

41760892

Abstract

The bone marrow endosteum provides a robust source of bone-making osteoblasts by housing various types of osteoblast precursor cells, including endosteal stem cells expressing fibroblast growth factor receptor 3 (Fgfr3) and their downstream progenitor cell populations. In fetal bone development, Dlx5 marks early perichondrial cells that populate the diaphyseal bone and marrow stroma in the postnatal stages. However, the location of Dlx5-expressing cells in the postnatal bone marrow and how they contribute to osteogenesis remain undefined. Here, we show that Dlx5

Published Open-Access

yes

Recommended Citation

Kondo, Keita; Matsushita, Yuki; Orikasa, Shion; et al., "Bone Marrow Endosteum Houses Hedgehog-Susceptible Dlx5-Expressing Osteoblast Precursor Cells" (2026). Faculty, Staff and Student Publications. 6364.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6364