Current States in Understanding Oligodendroglia-Mediated Neurological Issues in Neurofibromatosis Type 1 (NF1)

Authors

Benjamin E Aghoghovwia
Cheng-En Shen
Sabiha Bano
Nandini Shyamala
Alesandra Echeandia Marrero
Khushboo Irshad
Samer Sharafaldin
Nicole M Brossier
Yuan Pan

Language

English

Publication Date

9-29-2025

Journal

Acta Neuropathologica Communications

DOI

10.1186/s40478-025-02119-4

PMID

41024279

PMCID

PMC12482478

PubMedCentral® Posted Date

9-29-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Neurofibromatosis type 1 (NF1) is among the most common neurogenetic disorders and is associated with an increased risk of developing tumors in the nervous system. Additionally, up to 80% of patients with NF1 experience neurological complications, including deficits in attention, memory, and executive function. Significant effort has been dedicated to studying how NF1 mutations autonomously dysregulate neuronal function. Increasing evidence indicates that NF1 mutations also dysregulate the oligodendroglial lineage that contributes to neurological issues in NF1. Here, we summarize our current understanding of how NF1 mutations impact the oligodendroglial lineage homeostasis and plasticity. We also discuss gaps in knowledge, potential therapeutic strategies, and future directions.

Keywords

Humans, Neurofibromatosis 1, Oligodendroglia, Animals, Neurofibromin 1, Mutation, Neurofibromatosis type 1, Neuron-OPC crosstalk, Oligodendroglial lineage, Oligodendroglial plasticity, Gliomas

Published Open-Access

yes

Recommended Citation

Aghoghovwia, Benjamin E; Shen, Cheng-En; Bano, Sabiha; et al., "Current States in Understanding Oligodendroglia-Mediated Neurological Issues in Neurofibromatosis Type 1 (NF1)" (2025). Faculty, Staff and Student Publications. 6388.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6388