Faculty, Staff and Student Publications
Publication Date
10-3-2023
Journal
ACS Omega
DOI
10.1021/acsomega.3c02897
PMID
37810716
PMCID
PMC10552503
PubMedCentral® Posted Date
9-22-2023
PubMedCentral® Full Text Version
Post-print
Abstract
In the past few decades, advancements in protein engineering, biotechnology, and structural biochemistry have resulted in the discovery of various techniques that enhanced the production yield of proteins, targetability, circulating half-life, product purity, and functionality of proteins and peptides. As a result, the utilization of proteins and peptides has increased in the treatment of many conditions, including ocular diseases. Ocular delivery of large molecules poses several challenges due to their high molecular weight, hydrophilicity, unstable nature, and poor permeation through cellular and enzymatic barriers. The use of novel strategies for delivering protein and peptides such as glycoengineering, PEGylation, Fc-fusion, chitosan nanoparticles, and liposomes have improved the efficacy, safety, and stability, which consequently expanded the therapeutic potential of proteins. This review article highlights various proteins and peptides that are useful in ocular disorders, challenges in their delivery to the eye, and strategies to enhance ocular bioavailability using novel delivery approaches. In addition, a few futuristic approaches that will assist in the ocular delivery of proteins and peptides were also discussed.
Published Open-Access
yes
Recommended Citation
Boddu, Sai H S; Acharya, Devarshi; Hala, Vivek; et al., "An Update on Strategies to Deliver Protein and Peptide Drugs to the Eye" (2023). Faculty, Staff and Student Publications. 6400.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6400
Graphical Abstract
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Genetic Phenomena Commons, Medical Genetics Commons, Oncology Commons