Faculty, Staff and Student Publications

Language

English

Publication Date

8-1-2024

Journal

Current Opinion in Microbiology

DOI

10.1016/j.mib.2024.102493

PMID

38833793

PMCID

PMC127433v22

PubMedCentral® Posted Date

12-28-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Candida albicans is a ubiquitous fungus of humans. It is not only a component of the oral and intestinal microbiota of most healthy adults but also a major cause of mucosal disorders and life-threatening disseminated infections. Until recently, research on the biology and pathogenesis of the fungus was largely based on a single clinical isolate. We review investigations that have started to dissect a diverse set of C. albicans strains. Using different approaches to leverage the species' phenotypic and/or genetic diversity, these studies illuminate the wide range of interactions between fungus and host. While connecting genetic variants to phenotypes of interest remains challenging, research on C. albicans' natural diversity is central to understand fungal commensalism and pathogenesis.

Keywords

Candida albicans, Humans, Symbiosis, Genetic Variation, Candidiasis, Animals, Host-Pathogen Interactions, Gastrointestinal Microbiome

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.