Grading Melanocytic Dysplasia: Updated Histopathologic Criteria

Authors

Christopher R Shea
Victor G Prieto
Catherine M Shachaf
Scott R Florell

Language

English

Publication Date

1-1-2026

Journal

Journal of Cutaneous Pathology

DOI

10.1111/cup.14744

PMID

39532696

PMCID

PMC12711325

PubMedCentral® Posted Date

11-12-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and architectural elements of the Duke grading system to facilitate more detailed and precise assessment of dysplastic nevi.

Keywords

Humans, Skin Neoplasms, Dysplastic Nevus Syndrome, Melanocytes, Neoplasm Grading, World Health Organization, Melanoma, Nevus, Pigmented, dysplasia, dysplastic, grading, melanocytic, nevus

Published Open-Access

yes

Recommended Citation

Shea, Christopher R; Prieto, Victor G; Shachaf, Catherine M; et al., "Grading Melanocytic Dysplasia: Updated Histopathologic Criteria" (2026). Faculty, Staff and Student Publications. 6442.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6442