Early and Enduring: Targeting the Endothelium for Blood-Brain Barrier Protection

Authors

Silin Wu
Xuefang Sophie Ren
Yejie Shi

Language

English

Publication Date

9-1-2024

Journal

Journal of Cerebral Blood Flow & Metabolism

DOI

10.1177/0271678X241264086

PMID

38907363

PMCID

PMC11418723

PubMedCentral® Posted Date

6-21-2024

PubMedCentral® Full Text Version

Post-print

Abstract

The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.

Keywords

Blood-Brain Barrier, Humans, Animals, Endothelial Cells, Endothelium, Vascular, Brain Ischemia, Peroxiredoxins, Endothelial cell, inflammation, ischemic stroke, peroxiredoxin-4

Published Open-Access

yes

Recommended Citation

Silin Wu, Xuefang Sophie Ren, and Yejie Shi, "Early and Enduring: Targeting the Endothelium for Blood-Brain Barrier Protection" (2024). Faculty, Staff and Student Publications. 6456.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6456