Faculty, Staff and Student Publications

Language

English

Publication Date

8-20-2025

Journal

Journal of Cerebral Blood Flow & Metabolism

DOI

10.1177/0271678X251361250

PMID

40832973

PMCID

PMC12367713

PubMedCentral® Posted Date

8-20-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Cerebral edema (CE) is a major component of early brain injury from aneurysmal subarachnoid hemorrhage (SAH). Despite the utility of blood-based protein markers, biomarkers targeting cerebral edema have yet to be developed. We performed a targeted proteomic search analyzing 141 proteins in plasma samples taken from 80 adult patients within 48 hours after aneurysmal rupture to identify plasma biomarkers of cerebral edema. The protein expression profiles were analyzed for associations with a higher level of the subarachnoid hemorrhage early brain edema score measured in admission computed tomography scans. Five differentially expressed proteins-brorin, ectodysplasin A2 receptor, layilin, scavenger receptor class A member 5, and activin A receptor like type 1 (ACVRL1)-were identified. To confirm our findings, in a separate cohort of 75 adult patients with SAH, these biomarker candidates was analyzed using a different confirmatory analytic method-enzyme-linked immunosorbent assay-based on the plasma samples collected within 48 hours after aneurysmal rupture. ACVRL1 levels consistently showed a decrease expression levels as the severity of edema increased. The association between CE and ACVRL1 was significant before and after adjusting for patient factors.

Keywords

Activin A receptor like type 1, aneurysmal subarachnoid hemorrhage, cerebral edema, early brain injury, the subarachnoid hemorrhage early brain edema score

Published Open-Access

yes

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