Role of the Crosstalk B:Neoplastic T Follicular Helper Cells in the Pathobiology of Nodal T Follicular Helper Cell Lymphomas

Authors

Tania P Sainz
Vishal Sahu
Javier A Gomez
Nicholas J Dcunha
Akshay V Basi
Claudia Kettlun
Iman Sarami
Jared K Burks
Deepa Sampath
Francisco Vega

Language

English

Publication Date

11-1-2024

Journal

Laboratory Investigation

DOI

10.1016/j.labinv.2024.102147

PMID

39389311

Abstract

Angioimmunoblastic T-cell lymphoma (AITL), the most common form of peripheral T-cell lymphoma, originates from follicular helper T (Tfh) cells and is notably resistant to current treatments. The disease progression and maintenance, at least in early stages, are driven by a complex interplay between neoplastic Tfh and clusters of B-cells within the tumor microenvironment, mirroring the functional crosstalk observed inside germinal centers. This interaction is further complicated by recurrent mutations, such as TET2 and DNMT3A, which are present in both Tfh cells and B-cells. These findings suggest that the symbiotic relationship between these 2 cell types could represent a therapeutic vulnerability. This review examines the key components and signaling mechanisms involved in the synapses between B-cells and Tfh cells, emphasizing their significant role in the pathobiology of AITL and potential as therapeutic targets.

Keywords

Animals, Humans, B-Lymphocytes, Signal Transduction, T Follicular Helper Cells, Tumor Microenvironment, Lymphoma, T-Cell, Peripheral, Angioimmunoblastic T-cell lymphoma, B-cells, BCL-6, CD40-CD40L, CXCR5, ICOS, T follicular helper cells

Published Open-Access

no

Recommended Citation

Sainz, Tania P; Sahu, Vishal; Gomez, Javier A; et al., "Role of the Crosstalk B:Neoplastic T Follicular Helper Cells in the Pathobiology of Nodal T Follicular Helper Cell Lymphomas" (2024). Faculty, Staff and Student Publications. 6476.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6476