Clinical and Imaging Features of Head and Neck Metastasis of High-Grade Glioma: A Single-Center Case Series

Authors

Rami W Eldaya
Diana Kaya
Michelle Williams
Susana Calle
Dawid Schellingerhout

Language

English

Publication Date

1-8-2025

Journal

American Journal of Neuroradiology

DOI

10.3174/ajnr.A8521

PMID

39667825

PMCID

PMC11735445

PubMedCentral® Posted Date

1-1-2026

PubMedCentral® Full Text Version

Post-print

Abstract

High-grade gliomas are the most frequent primary brain tumors, yet extraneural metastasis is exceedingly rare. This is in part secondary to the relatively poor survival of these patients and likely the shielding effect of the blood-brain barrier. Given the rarity of extraneural metastasis, the pathophysiology and imaging appearance of extraneural metastasis is under-reported and poorly understood. In this case series we present 6 patients with pathology-confirmed high-grade glioma and extraneural head and neck metastasis. We highlight imaging features of metastasis on CT, MRI, and PET/CT. We also explore potential correlations and pathophysiology of high-grade glioma metastasis to the head and neck region.

Keywords

Humans, Glioma, Male, Middle Aged, Female, Head and Neck Neoplasms, Brain Neoplasms, Aged, Magnetic Resonance Imaging, Adult, Positron Emission Tomography Computed Tomography, Tomography, X-Ray Computed, Neoplasm Grading

Published Open-Access

yes

Recommended Citation

Eldaya, Rami W; Kaya, Diana; Williams, Michelle; et al., "Clinical and Imaging Features of Head and Neck Metastasis of High-Grade Glioma: A Single-Center Case Series" (2025). Faculty, Staff and Student Publications. 6495.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6495