Faculty, Staff and Student Publications
Publication Date
1-1-2023
Journal
Frontiers in Cardiovascular Medicine
Abstract
BACKGROUND: Traf2 and Nck-interacting kinase (TNIK) is known for its regulatory role in various processes within cancer cells. However, its role within endothelial cells (ECs) has remained relatively unexplored.
METHODS: Leveraging RNA-seq data and Ingenuity Pathway Analysis (IPA), we probed the potential impact of TNIK depletion on ECs.
RESULTS: Examination of RNA-seq data uncovered more than 450 Differentially Expressed Genes (DEGs) in TNIK-depleted ECs, displaying a fold change exceeding 2 with a false discovery rate (FDR) below 0.05. IPA analysis unveiled that TNIK depletion leads to the inhibition of the interferon (IFN) pathway [-log (
SUMMARY: Our findings suggest that TNIK plays a crucial role in regulating the EC response to virus infections through modulation of the IFN pathway.
Keywords
TNIK, interferons, STATs, virus infection, RNA-Seq
DOI
10.3389/fcvm.2023.1213428
PMID
38264262
PMCID
PMC10803426
PubMedCentral® Posted Date
January 2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Cardiology Commons, Cardiovascular Diseases Commons, Infectious Disease Commons, Internal Medicine Commons, Medical Sciences Commons
Comments
Supplementary Material
PMID: 38264262