Early Treatment Engagement and Long-Term Smoking Abstinence Among Women With Cervical Intraepithelial Neoplasia or Cervical Cancer

Authors

Charles E Hoogland
Steven K Sutton
Bethany Shorey Fennell
Vani N Simmons
Christine Vinci
Issam El Naqa
Ramzi G Salloum
Sanjay S Shete
Timothy Hembree
Damon J Vidrine
Jennifer I Vidrine

Language

English

Publication Date

8-1-2025

Journal

AJPM Focus

DOI

10.1016/j.focus.2025.100361

PMID

40673008

PMCID

PMC12264617

PubMedCentral® Posted Date

5-6-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Introduction: Cancer survivors who quit smoking have improved treatment response and decreased mortality. Although data indicate that greater tobacco cessation treatment engagement leads to better cessation outcomes in cancer survivors, little is known about how different tobacco treatment engagement patterns influence long-term cessation success. To help address this issue, this study examined how tobacco treatment engagement patterns predict cessation outcomes through 18 months and identified baseline participant characteristics predictive of treatment engagement patterns.

Methods: Data from a smoking-cessation RCT among women with a history of cervical intraepithelial neoplasia or cervical cancer comparing a 12-month, 6-session motivation and problem solving phone counseling intervention with standard treatment (tobacco quitline referrals) were analyzed. Treatment was completed remotely through self-administered nicotine replacement therapy and telephone counseling. Participants (n=202) were recruited in clinic in Oklahoma City and online nationally and randomly assigned to motivation and problem solving or standard treatment. Data from all 98 participants in motivation and problem solving alive at 18 months were included in the analyses.

Results: Controlling for baseline covariates, high total treatment engagement (i.e., completing ≥4 counseling sessions) predicted abstinence at 12 months (OR=11.37; 95% CI=2.34, 55.27; p=0.003) and 18 months (OR=12.71; 95% CI=1.42, 113.40; p=0.023). The best predictor of high total treatment engagement was high early treatment engagement (i.e., completing ≥3 counseling sessions within the first 3 months).

Conclusions: Given that few tobacco treatment interventions have demonstrated efficacy among cancer survivors, the current findings suggest a need for careful monitoring of treatment engagement and the possibility of making changes to treatment plans when early engagement is poor.

Keywords

Smoking cessation, cancer survivors, cervical cancer, cervical intraepithelial neoplasia, cancer, RCT

Published Open-Access

yes

Recommended Citation

Hoogland, Charles E; Sutton, Steven K; Fennell, Bethany Shorey; et al., "Early Treatment Engagement and Long-Term Smoking Abstinence Among Women With Cervical Intraepithelial Neoplasia or Cervical Cancer" (2025). Faculty, Staff and Student Publications. 6516.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6516