Texas Youth Depression and Suicide Research Network (TX-Ydsrn) Research Registry and Learning Healthcare Network: Rationale, Design, and Baseline Characteristics

Authors

Madhukar H Trivedi
Abu Minhajuddin
Holli Slater
Regina Baronia
Joseph C Blader
Jamon Blood
Ryan Brown
Cynthia Claassen
Melissa DeFilippis
David Farmer
Cynthia Garza
Jennifer L Hughes
Beth D Kennard
Israel Liberzon
Sarah Martin
Taryn L Mayes
Jair C Soares
Cesar A Soutullo
Eric A Storch
Sarah M Wakefield

Language

English

Publication Date

11-1-2023

Journal

Journal of Affective Disorders

DOI

10.1016/j.jad.2023.07.035

PMID

37459975

Abstract

Background: American youth are seriously impacted by depression and suicide. The Texas Youth Depression and Suicide Research Network (TX-YDSRN) Participant Registry Study was initiated in 2020 to develop predictive models for treatment outcomes in youth with depression and/or suicidality. This report presents the study rationale, design and baseline characteristics of the first 1000 participants.

Methods: TX-YDSRN consists of the Network Hub (coordinating center), 12 medical school "Nodes" (manage/implement study), each with 1-5 primary care, inpatient, and/or outpatient Sub-Sites (recruitment, data collection). Participants are 8-20-year-olds who receive treatment or screen positive for depression and/or suicidality. Baseline data include mood and suicidality symptoms, associated comorbidities, treatment history, services used, and social determinants of health. Subsequent assessments occur every two months for 24 months.

Results: Among 1000 participants, 68.7 % were 12-17 years, 24.6 % were ≥ 18 years, and 6.7 % were < 12. Overall, 36.8 % were non-Hispanic Caucasian, 73.4 % were female, and 79.9 % had a primary depressive disorder. Nearly half of the sample reported ≥1 suicide attempt, with rates similar in youth 12-17 years old (49.9 %) and those 18 years and older (45.5 %); 29.9 % of children < 12 reported at least one suicide attempt. Depression and anxiety scores were in the moderate-severe range for all age groups (Patient Health Questionnaire for Adolescents [PHQ-A]: 12.9 ± 6.4; Generalized Anxiety Disorder [GAD-7]: 11.3 ± 5.9).

Limitations: The sample includes youth who are receiving depression care at enrollment and may not be representative of non-diagnosed, non-treatment seeking youth.

Conclusions: The TX-YDSRN is one of the largest prospective longitudinal cohort registries designed to develop predictive models for outcome trajectories based on disorder heterogeneity, social determinants of health, and treatment availability.

Keywords

Child, Humans, Adolescent, Female, Male, Depression, Texas, Prospective Studies, Delivery of Health Care, Registries, Collaborative research network, Depression, Suicide, Treatment, Youth

Published Open-Access

yes

Recommended Citation

Trivedi, Madhukar H; Minhajuddin, Abu; Slater, Holli; et al., "Texas Youth Depression and Suicide Research Network (TX-Ydsrn) Research Registry and Learning Healthcare Network: Rationale, Design, and Baseline Characteristics" (2023). Faculty, Staff and Student Publications. 6549.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6549