α-Synuclein Seed Amplification Technology for Parkinson's Disease and Related Synucleinopathies

Authors

Claudio Soto

Publication Date

7-1-2024

Journal

Trends in Biotechnology

DOI

10.1016/j.tibtech.2024.01.007

PMID

38395703

PMCID

PMC11223967

PubMedCentral® Posted Date

7-1-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Synucleinopathies are a group of neurodegenerative diseases (NDs) associated with cerebral accumulation of α-synuclein (αSyn) misfolded aggregates. At this time, there is no effective treatment to stop or slow down disease progression, which in part is due to the lack of an early and objective biochemical diagnosis. In the past 5 years, the seed amplification technology has emerged for highly sensitive identification of these diseases, even at the preclinical stage of the illness. Much research has been done in multiple laboratories to validate the efficacy and reproducibility of this assay. This article provides a comprehensive review of this technology, including its conceptual basis and its multiple applications for disease diagnosis, as well for understanding of the disease biology and therapeutic development.

Keywords

alpha-Synuclein, Humans, Parkinson Disease, Synucleinopathies, Animals, Alpha-synuclein, Seed amplification assay, Parkinson’s disease, Diagnosis, Prion propagation

Published Open-Access

yes

Recommended Citation

Claudio Soto, "α-Synuclein Seed Amplification Technology for Parkinson's Disease and Related Synucleinopathies" (2024). Faculty, Staff and Student Publications. 6558.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6558