Faculty, Staff and Student Publications
Language
English
Publication Date
4-1-2024
Journal
Human Pathology
DOI
10.1016/j.humpath.2024.03.002
PMID
38460798
Abstract
Enhancer of zeste homolog 2 (EZH2) expression is found in about 40% of mantle cell lymphoma (MCL) patients, which is associated with aggressive histology, high Ki-67 proliferation rate, p53 mutant pattern and inferior overall survival (OS). We conducted 11-gene (ATM, BIRC3, CCND1, KMT2C, KMT2D, NOTCH1, NOTCH2, RB1, TP53, TRAF2 and UBR5) next generation sequencing panel to shed more light on MCL with EZH2 expression (EZH2+ MCL). EZH2+ MCL more frequently harbor TP53 mutation compared to EZH2(-) MCL (41.2% vs. 19.1%, respectively, p = 0.045). TP53 mutation and EZH2 expression demonstrated overlapping features including aggressive histology, high Ki-67 proliferation rate and p53 mutant pattern by immunohistochemistry. Comparative analysis disclosed that EZH2 expression correlates with high Ki-67 proliferation rate irrespective of TP53 mutation. Aggressive histology is associated with EZH2 expression or TP53 mutation, possibly via independent mechanisms. p53 mutant pattern is due to TP53 mutation. MCL patients with EZH2 expression or TP53 mutation show inferior outcome and when both are present, patients have dismal outcome.
Keywords
Humans, Enhancer of Zeste Homolog 2 Protein, Lymphoma, Mantle-Cell, Tumor Suppressor Protein p53, Mutation, Male, Female, Middle Aged, Aged, Biomarkers, Tumor, Aged, 80 and over, Adult, DNA Mutational Analysis, Immunohistochemistry, Ki-67 Antigen, Cell Proliferation
Published Open-Access
yes
Recommended Citation
Kim, Do Hwan; Siddiqui, Saima; Jain, Preetesh; et al., "TP53 Mutation Is Frequent in Mantle Cell Lymphoma With EZH2 Expression and Have Dismal Outcome When Both Are Present" (2024). Faculty, Staff and Student Publications. 6612.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6612
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