Faculty, Staff and Student Publications
Language
English
Publication Date
3-11-2025
Journal
International Journal of Molecular Sciences
DOI
10.3390/ijms26062502
PMID
40141147
PMCID
PMC11942263
PubMedCentral® Posted Date
3-11-2025
PubMedCentral® Full Text Version
Post-print
Abstract
The cholesterol biosynthesis pathway is upregulated during breast cancer development and progression. Inhibition of the aberrantly upregulated cholesterol pathway by statins reduces breast tumor incidence and burden by 50% in SV40 C3(1) TAg mice, a mouse model of triple negative breast cancer. We hypothesized that fluvastatin's preventive efficacy could be further enhanced by co-targeting the statin-induced restorative feedback pathways that tightly control the cholesterol pathway and are involved in resistance to statins. Acyl-coenzyme A: cholesterol acyltransferase (
Keywords
Animals, Fluvastatin, Female, Mice, Indoles, Fatty Acids, Monounsaturated, Humans, Cell Line, Tumor, Disease Models, Animal, Breast Neoplasms, Sterol O-Acyltransferase, Sterol O-Acyltransferase 2, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Cell Proliferation, Cholesterol, statin, avasimibe, TNBC, drug–drug interaction, mouse, breast cancer, prevention
Published Open-Access
yes
Recommended Citation
Bhardwaj, Anjana; Koh, Alexander; Bhala, Rhea; et al., "Avasimibe Abolishes the Efficacy of Fluvastatin for the Prevention of Cancer in a Spontaneous Mouse Model of Breast Cancer" (2025). Faculty, Staff and Student Publications. 6627.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6627
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