Recurrence-Free Survival Prediction for Anal Squamous Cell Carcinoma After Chemoradiotherapy Using Planning CT-Based Radiomics Model

Authors

Shanshan Tang
Kai Wang
David Hein
Gloria Lin
Nina N Sanford
Jing Wang

Language

English

Publication Date

2-1-2025

Journal

British Journal of Radiology

DOI

10.1093/bjr/tqae235

PMID

39535872

PMCID

PMC11751359

PubMedCentral® Posted Date

11-13-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Objectives: Approximately 30% of non-metastatic anal squamous cell carcinoma (ASCC) patients will experience recurrence after chemoradiotherapy (CRT), and currently available clinical variables are poor predictors of treatment response. We aimed to develop a model leveraging information extracted from radiation pretreatment planning CT to predict recurrence-free survival (RFS) in ASCC patients after CRT.

Methods: Radiomics features were extracted from planning CT images of 96 ASCC patients. Following pre-feature selection, the optimal feature set was selected via step-forward feature selection with a multivariate Cox proportional hazard model. The RFS prediction was generated from a radiomics-clinical combined model based on an optimal feature set with 5 repeats of nested 5-fold cross validation. The risk stratification ability of the proposed model was evaluated with Kaplan-Meier analysis.

Results: Shape- and texture-based radiomics features significantly predicted RFS. Compared to a clinical-only model, radiomics-clinical combined model achieves better performance in the testing cohort with higher concordance index (0.80 vs 0.73) and AUC (0.84 vs 0.78 for 1-year RFS, 0.84 vs 0.79 for 2-year RFS, and 0.85 vs 0.81 for 3-year RFS), leading to distinctive high- and low-risk of recurrence groups (P < .001).

Conclusions: A treatment planning CT based radiomics and clinical combined model had improved prognostic performance in predicting RFS for ASCC patients treated with CRT as compared to a model using clinical features only.

Advances in knowledge: The use of radiomics from planning CT is promising in assisting in personalized management in ASCC. The study outcomes support the role of planning CT-based radiomics as potential imaging biomarker.

Keywords

Humans, Anus Neoplasms, Chemoradiotherapy, Male, Carcinoma, Squamous Cell, Female, Middle Aged, Tomography, X-Ray Computed, Neoplasm Recurrence, Local, Aged, Retrospective Studies, Disease-Free Survival, Radiotherapy Planning, Computer-Assisted, Adult, Radiomics, anal squamous cell carcinoma, radiation treatment planning-CT, radiomics, recurrence-free survival prediction

Published Open-Access

yes

Recommended Citation

Tang, Shanshan; Wang, Kai; Hein, David; et al., "Recurrence-Free Survival Prediction for Anal Squamous Cell Carcinoma After Chemoradiotherapy Using Planning CT-Based Radiomics Model" (2025). Faculty, Staff and Student Publications. 6663.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6663